【摘要】 目的:检测慢性荨麻疹患者特异性免疫治疗(specific immunotherapy SIT)前后Th1型细胞因子白介素-18(IL-18)和Th2型细胞因子白介素-10(IL-10)血清水平。方法:ELISA法检测30例变应原皮肤试验阳性荨麻疹患者特异性免疫治疗前后及20例正常人血清IL-18和IL-10水平。结果:慢性荨麻疹患者SIT前IL-18水平低于正常人(P<0.05),SIT后升高(P<0.05);SIT前IL-10水平高于正常人(P<0.05),SIT后下降(P<0.05)。结论:变应原皮试阳性荨麻疹患者IL-18降低,IL-10升高,Th1/Th2失衡在慢性荨麻疹的发病中具有重要作用。特异性免疫治疗可能通过调节Th1/Th2平衡而发挥治疗作用。更多还原

【Abstract】 Objective: To determine the serum levels of Th1 cytokine IL-18 and Th2 cytokine IL-10 in chronic urticaria patients before and after specific immunotherapy(SIT).Methods: The serum levels of IL-18 and IL-10 in 30 cases of allergen positive patients with chronic urticaria and 20 healthy controls were measured by ELISA method before and after SIT.Results: Level of IL-18 was lower in chronic urticaria patients than that in controls(P<(0.05)).After SIT,IL-18 level was increased significantly(P<0.05).The level of IL-10 was higher in patients than in controls before SIT(P<0.05) and was decreased significantly after SIT(P<0.05).(Conclusion): There is low expression of Th1 cytokine IL-18 and high expression of Th2 cytokine IL-10 in allergen positive chronic urticaria.Th1 and Th2 unbalance perhaps plays an important role in chronic urticaria.SIT might adjust the balance between Th1 and Th2.更多还原