【摘要】 目的:探讨原发性皮肤间变性大细胞淋巴瘤(ALCL)临床及病理特征。方法:复习4例患者的临床资料、肿瘤组织的病理形态和免疫表型。结果:4例中男3例,女1例,平均年龄为55.5岁。患者临床上均表现为皮下结节。光镜下以75%以上CD30+间变性大细胞弥漫浸润真皮及皮下脂肪组织为特征,多数瘤细胞表达T细胞免疫表型。随访3例12~36个月肿瘤均无复发或转移。结论:原发性皮肤ALCL是少见的低度恶性T细胞性淋巴瘤,预后较好。依据其组织病理学特征及免疫组化CD30阳性标记,可与其他恶性肿瘤进行鉴别。更多还原

【Abstract】 Objective: To analyze the clinicopathologic characteristics of primary cutaneous anaplastic large cell lymphoma(ALCL).Methods: The clinical history,histopathological changes and immunohistochemical expression in 4 cases of primary cutaneous ALCL were investigated.Results: There were 3 males and 1 female with an average age of 55.5 years.All patients presented with subcutaneous masses.The lymphoma was characterized by a dermal and subcutaneous infiltration of atypical large cells.More than 75% of the neoplastic cells were CD30~+ and expressed T-cell immunophenotype.No recurrences or metastases were found in the follow-up of 3 cases for 12～36 months.(Conclusion): Primary cutaneous ALCL is a rare low-grade malignancy with a generally favorable outcome.This tumor can be differentiated from other malignant tumors by means of histopathologic features and positive expression of CD30.更多还原