【摘要】 目的:探讨中国湖北汉族慢性荨麻疹(CU)的发生与HLA-DRB1、DQB1等位基因间的关系。方法:应用聚合酶链反应-序列特异性引物(PCR-SSP)技术对已经确诊的湖北汉族CU42例和正常对照组193例进行HLA-DRB1、HLA-DQB1基因多态性分析。结果:患者组HLA-DRB112、0901等位基因频率较正常对照组显著增高(RR=3.11,χ2=7.579,P=0.006;RR=2.47,χ2=5.684,P=0.017),HLA-DQB105等位基因频率较正常对照组显著降低(RR=0.26,χ2=6.683,P=0.01)。结论:CU与HLA-DRB112、0901以及HLA-DQB105等位基因关联,前者是中国湖北汉族人CU的易感基因,而后者对CU有抵抗性。更多还原

【Abstract】 Objective: To determine the association of genotypes of HLA-DRB1 and DQB1 alleles with chronic urticaria. Methods: Genotypes of HLA-DRB1, HLA-DQB1 genes were detected by polymerase chain reactions with sequence-specific primers (PCR-SSP) in 42 patients with chronic urticaria and 193 racially matched healthy controls. Results: Gene frequencies of HLA-DRB1*12, *0901 were significantly increased in chronic urticaria patients as compared with healthy people (RR=3.11,χ2=7.579,P=0.006;RR=2.47,χ2=5.684,P= 0.017). Gene frequencies of HLA-DQB1*05 were significantly decreased in chronic urticaria patients(RR= 0.26,χ2=6.683,P=0.01). Conclusion: Chronic urticaria was strongly associated with HLA-DRB1*12, *0901 and HLA-DQB1*05, which suggests that the former may be the genetic markers for susceptibility to CU, but the latter may play a resistant role.更多还原