【摘要】 目的回顾性分析川崎病的临床特点、治疗及转归。方法对上海儿童医学中心1999年3月- 2004年2月收治的90例川崎病病例作一回顾性分析。结果发热,热程平均7．9 d;口唇潮红、皲裂 89例(98．9％);眼结膜充血84例(93.3％);四肢末梢脱皮80例(88．9％);多形性红斑、皮疹76例(84．41％);颈淋巴结肿大67例(74．4％);肛周脱皮49例(54．4％)。冠状动脉扩张14例(15．6％),冠状动脉扩张<4mm 9例,4-7 mm 3例,≥8mm 2例。82例(91．1％)在起病4-13 d内给予丙种球蛋白和阿司匹林治疗。冠状动脉扩张<4 mm 9例均在起病2个月内恢复正常,4—7 mm 2例在4个月内恢复正常,3例冠状动脉至今未恢复正常。结论对发热持续5 d的患儿不能用一般感染解释时,应给予严密的临床观察,不能排除川崎病在没有临床指征时,可给予大剂量丙种球蛋白。对川崎病合并冠状动脉瘤者应定期检查心电图及心脏超声, 对≥8 mm巨大冠状动脉瘤者应给予抗凝剂治疗。更多还原

【Abstract】 Objective To retrospectively analyze the clinical features, treatment and prognosis of Kawasaki disease(KD). Methods 90 KD patients hospitalized in Shanghai Children’s Medical Center from March 1999 to February 2004 were retrospectively analyzed. Results Among the 90 patients, all had fever, and fever durations were 7.9 days, 89 cases had lips injection and/or cheilosis(98.9%), 84 cases had conjunctivitis(93.3%), 76 cases had multiformal erythema(84.4%), 67 cases had cervical lymphadenopathy(74.4%), 49 cases had desquamation at the periphery of anus(54.4%), 14 cases had coronary artery extension(15.6%), and coronary artery extension in 9 cases were less than 4 mm, in 3 cases were 4~7 mm, in 2 cases were over 8 mm. APC and IVIG were given to 82 cases within 4~13 days from the onset, and 9 cases with less than 4 mm of coronary artery extension recovered to normal within 2 months from the onset, 2 cases with 4~7 mm of coronary artery extension recovered to normal within 4 months, but 3 cases had no recovery. Conclusion If KD is suspected, high dose of gamma globulin should be administered. Children with KD accompanied by coronary artery extension should have ECG and echocardiogram examinations on fixed days. Anticoagulants should be given to those with ≥8 mm of coronary artery extension.更多还原