【摘要】 目的探讨严重烧伤休克期血浆降钙素基因相关肽(CGRP)和神经肽Y(NPY)变化及其意义。方法采用放射免疫法(RA)测定60例严重烧伤患者休克期不同时相点血浆CGRP、NPY含量。结果严重烧伤休克期后3 h血浆CGRP降低,12 h达最低值,伤后48 h仍低于正常对照组(P<0.05);血浆NPY于伤后1 h升高,12 h达峰值,48 h仍高于正常对照组(P<0.05),血浆CGRP与NPY呈显著负相关(P<0.01)。结论血浆CGRP降低、NPY升高在严重烧伤休克期中起着重要作用,可能参与和促进了烧伤休克发生和发展。更多还原

【Abstract】 Objective To explore the changes of plasma Calcitonin gene-related peptide and neuropeptide Y levels after severe burn during shock stage and their clinic significance.Methods The plasma levels of CGRP and NPY in 60 patients with severe burn were measured by the method of radioimmunoassay at 1,3,6,12,24 and 48 hours.Results Plasma CGRP levels were decreased significantly at the 3hr after burn,reaching bottom value at the 12hr and remained lower than those in controls at 48hr(P<0.05).Plasma NPY concentrations were significantly increased at the 1hr after burn,reached peak value at the 12hr and remained higher than those in controls at 48hr(P(<0.05)).Plasma levels of CGRP were negatively correlated to plasma NPY levels(P<0.01).Conclusion CGRP level decrease and NPY level increase may play important roles during shock stage after severe burn.The change of CGRP and NPY levels has a great effect on the occurrence and development of burn shock.更多还原