【摘要】 目的:探讨发作间期FDGPET与发作期SPECT脑显像在小儿顽固性癫痫定位诊断中的价值。方法:对30例小儿顽固性癫痫患者行发作间期FDGPET与发作期SPECT显像,并对结果进行对比分析。结果:16例发作间期PET表现为局限性单叶代谢减低,14例表现为多灶或弥漫性改变。发作期SPECT显像18例为单叶局限性高灌注,10例为多处高灌注灶。30例患者中26例(86.7%)两项检查结果相符合,12例PET发作间期呈多病灶或弥漫性改变者,6例于发作期转化为单叶局限性病灶。结论:发作期SPECT结合发作间期PET显像,两者联合应用优势互补,可提高癫痫定位的准确性,为进一步治疗提供更可靠的信息。更多还原

【Abstract】 Objective: To evaluate the value of interictal PET and ictal SPECT brain imaging in localizing the foci of intractable epilepsy in children. Methods: Thirty pediatric patients with intractable epilepsy were performed with interictal PET and ictal SPECT brain imaging. The results were compared and analysed. Results: In interictal PET, 16 patients showed local single lobe hypo-metabolism, multi-lobe and diffuse hypo-metalism in 14 patients. During ictal SPECT studies, 18 showed hyper-perfusion in solitary lobe, multi-hyper-perfusion foci in 10 patients. Compared the two examinations, 26(86.7%) were accorded with each other in 30 patients. Of the 12 patients with multiple and diffuse hypometabolism in interictal PET, 6 patients showed foci changed to solitary focal hyper-perfusion in ictal SPECT. Conclusion: Interictal PET combined with ictal SPECT can learn from others’s strong points to offset one’s weakness, elevate the accuracy in localizing epileptic foci, offer more reliable messages for treatment.更多还原