【摘要】 目的:制备炎症显像剂99mTc-环丙沙星,并研究其在体内分布及炎症显像的方法,同时就此药物的体内分布特点进行分析,以评价其应用于临床的可行性。方法:研究标记物99mTc-环丙沙星的稳定性、小白鼠炎症模型体内分布并进行体外显像。结果:99mTc-环丙沙星标记率大于90%,室温下6h内化合物的放化纯稳定。小白鼠炎症组织与正常组织的放射性比值高,注射后1、4、6h,炎症组织与对侧正常组织比值分别为3.48、4.30、4.17。99mTc-环丙沙星主要由肝脏代谢、经肾脏排泄,血液清除较快。结论:99mTc-环丙沙星是一种灵敏度及特异性均高的炎症灶显像剂,且制备方法简单、方便。更多还原

【Abstract】 Objective: To prepare 99mTc-Ciprofloxacin(CPF), an inflammation tracer, and obtain the information about its biodistribution and scintigraphy in mice model, and assess its feasibility of clinical application. Methods: The stability of 99mTc-CPF, its biodistribution in mice model were studied, and 99mTc-CPF scintigraphy in mice model of inflammation was also performed. Results: The labelling rate of 99mTc-CPF was over 90%. 99mTc-Ciprotech was stable within 6 hours at room temperature. The inflammatory tissue/normal tissue were 3.48, 4.30 and 4.17 at 1, 4, 6 hour after injection respectively. The radioactivity clearance mainly occurred in the liver and kidney, and the clearance from blood was rapid. Conclusion: 99mTc-CPF is a specific and sensitive radiophamiaceutical agent for scintigraphy of inflammatory lesions, and it is easy to prepare.更多还原