【摘要】 目的探讨不同胎龄和不同日龄新生儿血清Cystatin C的变化。方法将60例新生儿根据胎龄分为5组,其胎龄分别为~32周、~34周、~37周、~40周、>40周,每组12例。将120例新生儿根据日龄分为6组,其日龄分别为~1 d、~3 d~、5 d、~7 d、~14 d、~28 d,每组20例。比较各组新生儿血清Cystatin C水平的差异。用微粒子增强免疫比浊法测定新生儿血清Cystatin C水平。结果(1)5组不同胎龄的新生儿出生时血清Cystatin C值分别为:(1.25±0.40)、(1.34±0.59)、(1.20±0.24)、(1.12±0.28)(、1.24±0.29)mg/L,差异无显著性意义(P>0.05)。(2)6组不同日龄的新生儿血清Cystatin C值分别为(1.30±0.34)(、1.28±0.42)(、1.22±0.37)(、1.29±0.37)(、1.28±0.46)(、1.18±0.35)mg/L,差异无显著性意义(P>0.05)。结论Cystatin C在新生儿期不受胎龄和日龄的影响,可作为评价新生儿期肾小球滤过功能的指标。更多还原

【Abstract】 Objective To investigate the dynamic changes of serum Cystatin C in neonates with different gestation age(GA) and day-age.Methods Sixty neonates were divided into 5 groups according to GA which were ～32,～34,～37,～40 and >40 weeks respectively,each group including 12 cases.One hundred and twenty neonates were divided into 6 groups according to day-age which were ～1,～3,～5,～7,～14 and ～28 days respectively,each group including 20 cases.The Cystatin C levels were compared among groups.The serum Cystatin C levels were measured with particle-enhanced immunoturbidimetry.Results The Cystatin C level of 5 groups with different GA were(1.25±0.40),(1.34±0.59),(1.20±0.24),(1.12±0.28) and(1.24±0.29)?mg/L respectively,showing significant difference among 5 groups(P>0.05).The Cystatin C level of 6 groups with different day-age were(1.30±0.34),(1.28±0.42),(1.22±0.37),(1.29±0.37),(1.28±0.46) and(1.18±0.35)?mg/L respectively.There were no significant difference among 6 groups(P>0.05).Conclusion The serum Cystatin C level is stable,the GA and day-age have not influence upon it in neonatal stage.Cystatin C may be an index to evaluate the function of the glomerular filtration rate in neonate.更多还原