【摘要】 目的探讨中枢神经系统(CNS)感染患儿脑脊液(CSF)中胰岛素样生长因子I(IGF-I)及神经元特异性烯醇化酶(NSE)变化的相关性。方法选择90例患儿,其中化脓性脑膜炎30例,病毒性脑膜炎30例,对照30例。所有受试者均于入院后24~48h做腰椎穿刺,采集CSF0·5~1ml,采用FJ-2008PSγ免疫计数器检测IGF-I及NSE含量。结果观察组CSF中IGF-I与NSE含量与对照组比较均差异显著(P<0·01);两观察组间比较,差异无显著性(P>0·05);两观察组间IGF-I与NSE测定值无相关性,但15例意识障碍患儿IGF-I及NSE两值间呈正相关。结论CNS感染时,CSF中IGF-I与NSE均明显增高,较重患儿的CSF中IGF-I和NSE值呈正相关,推测IGF-I在CNS损伤的保护和修复中发挥一定作用。更多还原

【Abstract】 Objective To explore the correlation between insulin-like growth factor-I (IGF-I) and neuron-specific enolase (NSE) in cerebrospinal fluid (CSF) of children with CNS infection.Methods 90 cases were recruited in the study,among which 30 cases were patients with bacterial meningitis (BM),30 cases with viral encephalitis (VM) and the rest belonged to contrast groups.CSF of all 90 cases was collected during the period from 24 to 48 hours after admission.IGF-I and NSE in CSF were measured by FJ-2008 PS γ immunocount instrument.Results Both BM and VM group had a significant difference in IGF-I and NSE as compared with control group (P<0.01),but there was no significant difference between BM and VM group (P>0.05).IGF-I and NSE in CSF of BM and VM group were not correlated with each other.However,IGF-I and NSE showed positive correlation in 15 patients with conscious disturbance (r=0.94,P<0.01).Conclusion Our study showed that IGF-I and NSE in CSF of patients with CNS infection increased greatly.IGF-I and NSE in CSF of critically ill children were correlated positively.It suggests that IGF-I play a certain role in protecting and repairing central nervous system.更多还原