【摘要】 目的:了解青银注射液对常见致病病毒的抑制作用,为临床用药提供理论依据。方法:体外试验,采用组织细胞培养法,观察药物对柯萨奇(CVB3)、疱疹病毒(HSV-Ⅱ)的抑制作用。体内试验,分别用CVB3、HSV-Ⅱ感染小鼠,经腹腔或静脉注射给药,观察小鼠存活天数,评价药物抗病毒作用。结果:体外试验,本品浓度105μg.ml-1以上,对CVB3、HSV-Ⅱ均有抑制作用;体内试验,本品对感染了HSV-Ⅱ的小鼠,4个给药剂量组小鼠存活天数均比阴性对照组明显延长(P<0.01),具有较好的量效关系。结论:青银注射液对疱疹病毒的抑制作用强,而对柯萨奇病毒的抑制作用稍弱。更多还原

【Abstract】 Objective: To investigate the inhibition of Qingying injection on common viruses.Methods: In vitro test: the inhibition on CVB₃ and HSV-Ⅱ was observed through cell cultivation method.In vivo test: mice were infected by CVB₃ and HSV-Ⅱ respectively.Qingying injection was administered into their abdominal cavity and vein. The survival time（days） was observed to estimate the anti viral effect of the drug.Results: The in vitro test showed that the drug with a concentration more than 105μg·ml^-1 has inhibitive effect on CVB₃ or HSV-Ⅱ.The in vivo test showed that all the dosage groups survived for more days than the control group,which exhibits a good dosage-effect relationship.Conclusion: Qingying injection has strong inhibition on HSV-Ⅱ.It is slightly weaker on CVB₃,though.更多还原