【摘要】 目的观察雷帕霉素洗脱支架(CypherTM)对急性冠状动脉综合征(acutecoronarysyndrome,ACS)的疗效。方法选择住院的接受雷帕霉素洗脱支架植入的ACS83例,在支架植入术后9个月内,进行电话或门诊随访,冠状动脉造影或冠状动脉螺旋CT扫描,计算不良心脏事件发生率,评价合并糖尿病及其它病变的疗效。结果83例患者共植入支架112枚,植入成功率为98.8%。接受冠状动脉造影29例(34.9%),接受冠状动脉螺旋计算机断层扫描1例。发生主要不良心脏事件10例,发生率12.0%,其中猝死1例,再发心肌梗死1例,再次血运重建8例(1例为新的病变),与支架相关的再狭窄及血栓事件发生率为10.8%(9/83);糖尿病、弥漫病变、重叠支架、高血脂时再狭窄率分别为13.3%,11.1%,11.1%和8.5%。结论雷帕霉素洗脱支架治疗ACS安全、可靠;弯曲、弥漫、较长的冠状动脉病变或合并糖尿病者,出现再狭窄的概率增加。更多还原

【Abstract】 Objectives To evaluate the efficacy of CypherTM drug eluting stent in the treatment of patients with acute coronary syndrome(ACS).Methods A total 83 acute coronary syndrome patients undergone coronary artery cypherTM drug eluting stenting(DES) received follow up by telephone and angiography or coronary antery super-speed CT to evaluate the rate of major adverse cardiac event(MACE) and the efficacy of with diabetes mellitus(DM) and other complicated lesions during 9 months.Results One hundred-twelve stents were implantation in 83 patients.The success rate of stent implantation was 98.8%( 82/83),29 patients received angiography check,one by super-speed CT.The overall rate of MACE were 12% with 10 patients,including 1 sudden death,1 acute myocardial infarction(AMI),8 lesion revascularization( TLR),The total restenosis rate that connected with DES was 10.8%(9/83),and among it 13.3% was DM patients,11.1% with diffuse lesion and overlapping stent,8.5% with hypercholesterolemia.Conclusions CypherTM is safe and effective in ACS patients,but there are a few rate of restenosis with cross,diffuse lesion,overlapping stent,DM and hypercholesterolemia patients.更多还原