【摘要】 目的探讨高脂血症时血管活性物质的改变及辛伐他汀对内皮依赖的舒张功能的影响。方法检测高脂血症动物模型大鼠的血脂、血和心肌组织一氧化氮(nitricoxide,NO)、心血管紧张素Ⅱ(AngiotensinⅡ,AngⅡ)水平及辛伐他汀治疗16周后的改变。结果高脂血症组血和组织NO水平低于正常对照组,但AngⅡ、血管内皮生长因子(vascularendothelialgrowthfactor,VEGF)水平、血压和心脏质量与对照组差异无统计学意义。辛伐他汀治疗第20周时甘油三酯、低密度脂蛋白胆固醇显著低于非治疗组,且血NO、VEGF和组织NO浓度高于非治疗组。结论高脂血症时血和心肌组织NO水平低,而辛伐他汀可逆转此改变,可能与影响血管内皮生长因子的分泌有关。更多还原

【Abstract】 Objectives To study the impact of hyperlipidemia on vasoactive substances and the mechanism of simvastatin in regulating the endothelial function. Methods We produced the hyperlipidemic model with rats. The serum levels of lipid, NO, AngⅡ, vascular endothelial growth factor (VEGF) and myocardial levels of NO, AngⅡ were measured. Results Hyperlipidemic rats had lower level of NO compared with those of control subjects, but no difference in ANG II, VEGF, SBP and myocardial weight. Administration of simvastatin significantly elevated serum VEGF, NO and myocardial NO level. Conclusions Hyperlipidemia is associated with not only reduced serum NO but reduced myocardial NO that could cause endothelial dysfunction. VEGF might involve in regulating endothelial function which is contributed to the protective effects of simvastatin besides lipid-lowering.更多还原