【摘要】 目的探讨氨溴索对体外循环(cardiopulmonarybypass,CPB)所致炎性反应的影响。方法选择浅低温不停搏心脏瓣膜置换术患者30例,随机分为氨溴索组和对照组,每组15例。氨溴索组于CPB前,CPB30min及CPB结束3个时点分别静脉注射氨溴索150mg。对照组在相应时点给与生理氯化钠10ml。于CPB前、CPB结束后即刻、CPB结束后2h、24h等时点采集血标本,检测血清肿瘤坏死因子(tumornecrosisfactor-α,TNF-α)与白介素8(interteukin-8,IL-8),并且在采样的各时点进行血气分析,计算呼吸指数。结果CPB结束即时、2h、24h,对照组TNF-α明显高于CPB前及相同时点氨溴索组的浓度(P<0.05)。结论氨溴索可减轻浅低温心脏不停搏术CPB所致的炎性反应。更多还原

【Abstract】 Objectives To evaluate the effects of ambroxol on the inflammation response induced by caldiopulmonary bypass. Methods Thirty patients with mitral valve replacement by mild hypothermia beating heart surgery were randomly divided into ambroxol group(15 patients)and control group(15 patients). Observation time-point as fellows: before cardiopulmonary bypass(CPB), end of CPB, 2 h after CPB and 24 h after CPB. In the ambroxol group, ambroxol was injected before CPB, at CPB 30 min, and end of CPB, saline was injected at same time-point in the control group. Serum TNF-a, IL-8, blood gas and respiratory index were detected at these time-points. Results In the time-points of end of CPB, 2 h and 24 h after CPB, the levels of serum TNF-α, IL-8 were significantly higher than before cardiopulmonary bypass in the control group, and the levels of serum TNF-α,IL-8 in the ambroxol group were significantly lower than those in the control group in the same time-points. Conclusions Ambroxol can alleviate the inflammation response induced by cardiopulmonary bypass in the mild hypothermia beating heart surgery.更多还原