【摘要】 目的:总结小儿血小板减少性紫癜(ITP)的临床特点,探讨其发生与病毒感染的关系及治疗。方法:对本科2004年6月至2006年6月间住院的44例ITP患者的临床资料进行回顾性分析。结果:急性ITP占68%,慢性ITP占32%;男女比例为1.75:1;PAIgG升高占75%,PAIgA升高占5%;发病1～6周前有明确前驱感染者24例(54%);检测到巨细胞病毒(CMV)、EB病毒(EBV)、人微小病毒B19感染的急性病例5例(17%),慢性病例11例(79%);在传统治疗方法外,采用更昔洛韦、磷甲酸钠清除病毒感染,急性病人全部治愈,慢性病人疗效提高。结论:ITP特别是慢性病例的发生与病毒感染密切相关,采用更昔洛韦、磷甲酸钠清除病毒,可提高疗效。更多还原

【Abstract】 Objective: To study the clinical features of children idiopathic thrombocytopenic purpura (ITP) and to explore its association with viral infection and its treatment. Method:The clinical data of 44 patients who were hospitalized with ITP during 2004.6～2006.6 was retrospectively analyzed. Results:The incidence of acute cases was 68% and the chronic ones was 32%; the ratio of male to female was 1.75∶1. The elevated level of PAIgG was found in 75% patients and PAIgA was in 5%. The occurrence of preliminary infection was found in 24 cases (54%) 1～6 weeks before ITP was diagnosis. 5(17%) of the acute cases had infections of cytomegalovirus?EB virus or human parvovirus B19, and the data of chronic cases was 11(79%). Besides the ordinary treatment, ganciclovir and foscarnet sodium were used to clear(the viruses. The acute patients were all cured, and the cure rate of chronic group was elevated. Conclusions: Chronic ITP was associated with the infection of viruses,ganciclovir and foscarnet sodium have efficacy for treatment of ITP by clearing virus.更多还原