成人急性白血病免疫学分型的研究

【摘要】 目的探讨成人急性白血病(AL)抗原表达规律。方法通过流式细胞术检测140例成人急性白血病患者免疫分型情况。结果(1)104例急性髓系白血病(AML)患者主要表达CD13、CD33、HLA-DR、CD34和CD117抗原,26.9%的AML患者伴有淋系抗原的表达;(2)30例急性淋巴细胞白血病(ALL)患者主要表达HLA-DR、CD10、CD19、CD34和CD7。40%的ALL患者伴有髓系抗原的表达。结论本方法能直接准确的反映成人急性白血病的的免疫学分型,有利于成人急性白血病的诊断、治疗及预后判断。更多还原

【Abstract】 Objective To explore the criteria and significance of Immunophenotye for adult acute leukemia. Methods Immunophenotye was performed in 140 adult patients with acute leukemia by flow cytometry. Results The antigens expressed in 104 patients with acutemyeloid lecukemia（AML） were mainly CD 13 , CD 33 ,HLA-DR,CD 34 and CD 117 . Lymphoid antigen expression was identified in 26.9% adult AML patients. In 30 patients with acute lymphoblastic leukemia（ALL）,the expressed antigens were mainly HLA-DR,CD 10 ,CD 19 ,CD 34 and CD₇,and 40% of these patients were found to be positive for myeloid antigen expression. Conclusion The criteria can reflece the characteristic of immunophenotype of adult acute leukemia directly and exactly, and it can play an important role in diagnosis,treatment and predicting prognosis for adult acute leukemia.更多还原