【摘要】 [目的]探讨强化SOD刺梨汁对燃煤型砷中毒患者脂质过氧化作用的影响及其作用机制。[方法]采用生化法分别测定强化SOD刺梨汁、刺梨汁治疗前后患者血中超氧化物歧化酶(superoxidedismutase,SOD)、谷胱甘肽过氧化物酶(glutathioneperoxidase,GSH-PX)及谷胱甘肽硫转移酶(glutathione-s-transferase,GST)的活性,谷胱甘肽(glutathione,GSH)及巯基(hydrosulfidegroup,-SH)含量和丙二醛(malondialdehyde,MDA)水平。[结果]强化SOD刺梨汁治疗后患者的SOD、GSH-PX及GST活力均较治疗前明显升高,GSH及-SH含量显著增加,MDA水平则明显降低(P<0.05或P<0.01);刺梨汁治疗后患者的SOD、GSH-PX及GST活力亦较治疗前显著提高(P<0.05),但GSH-SH含量及MDA水平在治疗前后差异不显著;与刺梨汁治疗组比较,强化SOD刺梨汁组患者的SOD活性及-SH含量显著提高(P<0.05),MDA水平明显降低(P<0.05)。[结论]强化SOD刺梨汁可提高燃煤型砷中毒患者机体抗氧化物质的活性或含量,拮抗砷中毒自由基脂质过氧化的损害作用。强化SOD刺梨汁的作用优于单纯刺梨汁。更多还原

【Abstract】 Objective To study the influence of SOD-enriched cili juice on oxidative damage in arsenism patients caused by burning coal and to investigate its mechanism. Methods Biochemical methods were used to measure the activity of superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)and glutathione-s-transferase(GST),the contents of glutathione (GSH),hydrosulfide group(-SH)and the level of malondialdehyde(MDA)in the patients before and after treatment with SOD- enriched Cili juice and ordinary cili juice respectively. Results After the treatment of SOD-enriched cili juice,the activity of SOD,GSH-Px and GST,the contents of GSH and -SH of the patients significantly increased,but MDA contents obviously decreased(P < 0.05 or P < 0.01). While after the treatment of ordinary cili juice,although the activity of SOD,GSH-Px and GST also increased significantly(P < 0.05),but GSH,-SH and MDA didn’t show significant changes before and after treatment. Comparing with the ordinary cili juice treated group,the activity of SOD and the contents of -SH in SOD-enriched cili juice group significantly increased(P < 0.05),the level of MDA obviously decreased(P < 0.05). Conclusion SOD-enriched cili juice can increase the activity or the contents of anti-oxidation materials in arsenism patients. It can antagonize the free radicals’ lipid peroxidation of arsenism. The effects of SOD-enriched cili juice are better than that of ordinary cili juice.更多还原