【摘要】 目的比较丙泊酚靶控输注(TCI)静脉给药与手推静脉给药麻醉对无痛人流手术的影响。方法将220例人流术者随机分为2组,Ⅰ组:TCI泵推注丙泊酚,靶质量浓度设定为6~7 mg.L-1,维持时靶质量浓度设定为4~5 mg.L-1,手术结束时停止输药;Ⅱ组:静脉推注给药,丙泊酚诱导量2~2.5 mg.kg-1,手术期间追加丙泊酚50 mg左右。分别观察2组诱导、苏醒时间、总药量、麻醉效果及诱导前后平均动脉压、心率、动脉血氧饱和度的变化。结果Ⅰ组诱导、苏醒时间、用药量均少于Ⅱ组(P<0.01);2组诱导后平均动脉血压、心率、血氧饱和度均低于术前(P<0.05),Ⅱ组下降更严重;麻醉效果Ⅰ组优于Ⅱ组(P<0.05)。结论靶控输注丙泊酚麻醉用于人工流产手术可以减少麻醉用药量,缩短麻醉诱导、苏醒时间,有较好的麻醉效果。更多还原

【Abstract】 AIM To compare the anesthetic effects of propofol by target-controlled infusion（TCI） by venous injection during painless artificial abortion.METHODS Two hundred and twenty patients scheduled for painless artificial abortion were randomly divided into 2 groups : TCI group（group Ⅰ） and venous injection group（group Ⅱ）.In group Ⅰ,the anesthesia was induced dosage at 6-7 mg·L^-1 by TCI with propofol,maintained at 4-5 mg·L¹,stopped injecting when operation end.In group Ⅱ: propofol was injected, induced dosage at 2-2.5 mg·kg^-1,propofol could be added about 50 mg during the operation.The induction time,recovery time,the total dose of propofol and anesthetic effects in 2 groups were compared.Mean arterial pressure（MAP）,HR,arterial oxygen saturation（SaO₂） were recorded before and after induction.RESULTS The induction time,recovery time and total dosage in group Ⅰ were all less than those in group Ⅱ（P<0.01）.MAP,HR and SaO₂ after induction in 2 groups were all lower than those before induction（P<0.05）,especially in group Ⅱ.The anesthesia effect was significantly better in group Ⅰ than in group Ⅱ（P<（0.05））.CONCLUSION Target-controlled infusion propofol in painless artificial abortion can decrease the dose requirement of propofol, shorten the time of induction and recovery,increase anesthetic effect.更多还原