【摘要】 目的:回顾性分析鼻咽未分化癌与鼻咽低分化鳞癌的疗效及预后因素。方法:应用Kaplan-Meier法及Cox分析69例鼻咽未分化癌与随机抽取同期收治的69例鼻咽低分化鳞癌的临床资料。结果:鼻咽未分化癌与低分化鳞癌皆以中晚期病例为主,Ⅲ、Ⅳ期病例皆占75.4%,治疗后,两者的生存率差异无统计学意义(P=0.9535)。未分化癌中Ⅲ、Ⅳ期病例,放化疗组5年生存率51.5%,而单纯放疗组的5年生存率为36.8%,放化疗组与单纯放疗组的生存率差异有统计学意义(P=0.0486)。而对低分化鳞癌,两者的生存率差异无统计学意义(P=0.413)。结论:鼻咽未分化癌与鼻咽低分化鳞癌在TNM分期及治疗后生存率上无显著性差异。对Ⅲ、Ⅳ期未分化癌,联合放化疗较单纯放疗可提高其生存时间。Cox分析显示生存时间仅与TNM分期有关。更多还原

【Abstract】 Objective:To retrospectively analyze the therapeutic efficacy and prognosis of undiffbrentiated and low-differentiated nasopharyngeal carcinomas.Methods:Retrospective analysis were done upon 69 undifferentiated NPC cases and 69 low-differentiatcd NPC cases which were selected by random from 1995 to 2001 according to Kaplan-Meicr and Cox regression analysis.Results:Advanced cases of stage Ⅲ,Ⅳ remained major in undifferentiated NPC and low-differentiated NPC,accounting for 75.4% respectively.Their survival rates had no significant difference(P=0.953 5).In the cases of undiffeerentiated NPC at stage Ⅲ,Ⅳ,5 years survival rate was 51.5% treated by radiotherapy combined with chemotherapy,meanwhile it was 36.8% by radiotherapy alone.Their survival rates had significant difference(P=0.048 6).But to low-differentiated NPC,there’s no significant difference(P=0.413).Conclusion:In clinical stage and survival time,there’s no significant difference between undifferentiated NPC and low-differentiated NPC after treatment.Radiotherapy combined with chemotherapy can improve survival time compared with radiotherapy alone.Cox regression analysis showed that only TNM stage was the most significant prognosis factor.更多还原