【摘要】 目的:评价周剂量紫杉醇(PTX)联合氟尿嘧啶(5-FU)、顺铂(DDP)和醛氢叶酸(CF)组成PLFP方案治疗晚期食管癌的临床疗效和毒副反应。方法:32例Ⅲ、Ⅳ期晚期食管癌患者,给予周剂量PTX+LFP(CF+5-FU+DDP),即PTX80mg/m2,ivgttqw,连续2周;DDP80mg/m2,ivgtt,分为3~5d;5-FU500mg/m2,ivgttd1~d5;CF100mg/次,ivgtt,在5-FU前2h内给药,d1~d5,21d为1周期,2周期后按UICC标准评价近期疗效和毒副反应。结果:全组32例,全都可评价疗效,总有效率62·5%,22例初治组有效率为68·2%,其中CR3例。10例复治组有效率为50%,其中CR1例。毒副作用主要为剂量限制性毒性,表现为Ⅱ~Ⅲ度为主的骨髓抑制。结论:周剂量紫杉醇联合氟尿嘧啶、顺铂和醛氢叶酸组成的PLFP方案可能是治疗晚期食管癌较好的化疗方案,值得进一步观察。更多还原

【Abstract】 Objective:To evaluated the efficacy and toxicity of weekly Paclitaxel(PTX) combined with 5-Fluorouracil(5-FU), DDP and CF as alternative chemotherapy for patients with advanced esophageal carcinoma.Methods:Thirty-two patients were enrolled in the study. Each was treated as following: PTX 80mg/m2 infusion per week for two weeks; DDP 80mg/m2 infusion on days 1～3 or days 1～5; 5-FU 500mg/m2/d infusion on days 1～5; CF 100mg/d infusion 2 hours before 5-FU infusion on days 1～5. After 2 consecutive treatment course, each for 21days, evaluation of the short-term efficacy and adverse effects was carried out.Results:The overall response rate was 62.5%. The response rates of 22 patients in primary treatment was 68.2%( 3 cases CR) and that of relapse treatment was 50%(1 case CR). The dose-limited toxicity was mild and mainly expressed as bone marrow depression(grade Ⅱ～Ⅲ).Conclusion:Weekly Paclitaxel(PTX) combined with 5-Fluorouracil(5-FU), DDP and CF as alternative chemotherapy is encouraging for patients with advanced esophageal carcinoma.更多还原