【摘要】 目的：探讨慢性阻塞性肺病（COPD）患者急性发作期和缓解期血清IL-8和MMP-9变化的临床意义。方法：采用ELISA方法,分剐检测23例患者在COPD急性发作期、缓解期及20例正常人血清IL-8和MMP-9水平,并进行比较。结果：COPD急性发作期IL-8水平（197.27±65.44）pg·ml^-1明显高于缓解期（39.94±9.55）pg·ml^-1（P＜0.01）,两者间血清MMP-9水平则无显著差异（P＞0.05）。COPD急性发作期和缓解期血清MMP-9水平分别为（206.10±50.88）ng·ml^-1和（190.09±43.22）ng·ml^-1均明显高于正常人（150.04±61.50）ng·ml^-1（P＜0.01）。结论：IL-8参与了COPD的炎症过程,其血清水平有助对COPD急性发作进行监测。MMP-9在COPD急性发作期和缓解期都有高水平表达,可能与气道重塑、肺气肿形成有关。更多还原

【Abstract】 Objective:To study the variation and significance of IL-8 and MMP-9 in patients with chronic obstructive pulmona- ry disease(COPD) during an acute exacerbation and at stable period.Methods:Enzyme-linked immunosorbent assay was used to messure the serum levels of IL-8 and MMP-9 in 20 normal person,23 patients with COPD during an acute exacerbation and at a stable period.Results:The serum level of IL-8 in patients with COPD during an acute exacerbation was significantly high- er than that of at stable period (P＜0.01).The serum level of MMP-9 did not differ significantly in acute exacerbation com- pared with stable period (P＞0.05),but the serum levels of MMP-9 in acute exacerbation and stable period were both signifi- cantly higher than that of normal person (P＜0.01).Conclusion:IL-8 takes part in the inflammation activity,its serum level is good for determining the condition of COPD during an acute exacerbation.The serum level of MMP-9 in patients with COPD during an acute exacerbation and at stable period are both higher,MMP-9 may be involved in the airway remodeling,correlated with the pulmonary emphysema.更多还原