【摘要】 目的:评价血清白细胞介素(IL)-18、肿瘤坏死因子α(TNF-α)和IL-10水平与急性冠状动脉综合征(ACS)的关系及其临床意义。方法:冠心病(CHD)患者91例,分为ACS组、稳定型心绞痛(SAP)组;非CHD患者55例作为对照组,采用ELISA法测定血清IL-18、TNF-α和IL-10浓度并分析。结果:CHD患者血清IL-18和TNF-α水平明显高于对照组(P<0.01),而血清IL-10明显低于对照组(P<0.01);与SAP组相比,ACS组血清IL-18和TNF-α水平明显升高(P<0.01),而血清IL-10水平则显著降低(P<0.01)。且随着冠状动脉狭窄程度的增加,IL-18的水平逐渐增高。结论:IL-18、TNF-α和IL-10可以反映动脉粥样硬化斑块的严重程度和稳定状态,可作为监测病情的临床生化指标。更多还原

【Abstract】 Objective:To study the relations of the levels of serum interleukin-18(IL-18), tumor necrosis factor-α(TNF-α) and interleukin-10(IL-10) with acute coronary syndrom(ACS) and their clinical significance. Method:Sixty patients with ACS, including 31 patients with SAP and 55 health persons, were studied. The concentration of serum IL-18,TNFα and IL-10 was measured with ELISA. Result:The levels of serum IL-18 and TNFα in patients with coronary heart disease were significantly higher than those in health persons(P<0.01), Whereas the levels of IL-10 were lower(P<0.01). Compared with SAP group,ACS group had higher levels of serum IL-18 and TNF-α (P<0.01) and lower levels of serum IL-10 (P<0.01).Conclusion :The concentration of serum IL-18,TNF-α and IL-10 reflecst the severity and unstable status, thus can be used clinically as a monitor.更多还原