【摘要】 目的:观察维吾尔族男性急性冠状动脉综合征(ACS)患者血清脂蛋白(a)[LP(a)]、血浆纤溶酶原激活抑制物-Ⅰ(PAI-Ⅰ)及血浆纤维蛋白原(Fg)水平变化并分析其相关性。方法:维吾尔族男性119例,分为2组: ACS组66例,对照组53例;分别测定其血清LP(a)、血浆PAI-Ⅰ和血浆Fg水平。结果:ACS组、对照组血清LP (a)分别为(422．323±201．685)、(146．60±80．984)mmol／L;2组血浆PAI-Ⅰ含量吸收度(A值)分别为(1．276 ±0．831)和(0．369±0．418);血浆Fg水平分别是(4．688±0．970)、(3．515±0．507)g／L,2组间差异均有统计学意义(P<0．05)。将119例研究对象,按LP(a)分为≤300 mmol／L组和>300 mmol／L,比较2组PAI-Ⅰ含量和 Fg水平:LP(a)>300 mmol／L组(55例)A值为(1．182±0．842),Fg为(4．563±0．980)g／L;LP(a)≤300 mmol／ L组(64例),A值为(0．605±0．691),Fg为(3．824±0．864)g／L,经秩和检验2组间差异具有统计学意义(P< 0．01)。血清LP(a)与血浆PAI-Ⅰ含量相关分析,r=0．427,P<0．01;血清LP(a)与血浆Fg进行相关分析,r =0．441,P<0．01。结论:血清LP(a)、血浆PAI-Ⅰ和血浆Fg水平在维吾尔族男性ACS患者中明显增高;血清 LP(a)水平高者血浆PAI-Ⅰ及Fg亦有较高水平,血清LP(a)水平与血浆PAI-Ⅰ、Fg水平间呈正相关。维吾尔族男性LP(a)、PAI-Ⅰ和Fg水平增高与其冠心病临床事件的发生有关。更多还原

【Abstract】 Objective: To investigate the changes and the correlation between lipoprotein(a) (LP[a]), plasminogen activator inhibitor- Ⅰ (PAI- Ⅰ ) and fibrinogen(Fg) in uigur male patients with acute coronary syndromes (ACS). Method:The serum LP(a) ,absorb( A ) of the plasma plasminogn activator inhibitor-Ⅰ and the plasma Fibrinogen were detected in 119 uigur males. Sixy-six patients with acute coronary syndromes were enrolled as ACS group;the other 53 patiens without coronary heart disease(CHD) were enrolled as control group. Result: There were significant differences in serum LP(a) , plasma PAI- Ⅰ , and Fg between the ACS group and the control group (LP(a) [422. 323 ±201. 685]mmol/L vs [146. 60±80. 984]mmol/L; PAI-Ⅰ [1. 275 8±0. 831 2]vs [0. 3686±0. 4178]; Fg[4. 6883±0. 9697]g/L vs [3. 5145±0.5068]g/L, F <0. 05. The levels of PAI-Ⅰ in the subjects with LP(a)>300 mmol/L( n =55) were 1. 182 5±0. 841 7,and the levels of Fg in them were (4. 5625±0.9797) g/L, while the levels of PAI- Ⅰ with LP(a)≤300 mmol/L( n =64) were 0. 6047 7±0. 6905 7,and their levels of Fg were (3. 8244±0. 8640)g/L. There were significant differences between two groups . There is positive correlation between the levels of LP(a) and PAI- Ⅰ ( r =0. 427, P <0. 001),and between the levels of LP(a) and Fg ( r = 0. 441, P<0. 01). Conclusion:The Uigur male patients with ACS had significantly increased levels of LP(a) ,PAI-Ⅰ ,Fg, and the subjects who had higher levels of LP(a) had higher levels of PAI-Ⅰ and Fg simultaneously. It proved that LP(a) , PAI- Ⅰ and Fg may be risk factors of CHD in Uigur male patients.更多还原