【摘要】 目的探讨能动性相关蛋白-1(MRP-1/CD9)和缺氧诱导因子-1α(HIF-1α)在膀胱移行细胞癌中的表达及临床意义。方法采用免疫组化SP法观察46例膀胱癌石蜡标本中MRP-1/CD9和HIF-1α的表达情况,结合临床资料进行分析。结果膀胱癌组织中MRP-1/CD9和HIF-1α的阳性表达率分别为56.5%和43.5%。MRP-1/CD9阳性表达率在复发肿瘤中及随病理分级升高而下降(P<0.05),但与临床分期无关(P>0.05);HIF-1α的阳性表达率在复发肿瘤中及随病理分级、临床分期升高而升高(P<0.05)。MRP-1/CD9和HIF-1α的阳性表达率无显著相关性(P>0.05)。结论MRP-1/CD9和HIF-1α的表达可能是判断膀胱癌生物学行为的重要指标。更多还原

【Abstract】 Objective To investigate the expression of MRP-1/CD9 and HIF-1α in bladder transitional cell carcinoma and its clinical significance.Methods The MRP-1/CD9 and HIF-1α expression was detected in 46 specimens by SP of immunohistochemistry.The results were analyzed in relation to the clinical data.Results The positive rate of MRP-1/CD9 and HIF-1α in bladder carcinoma was 56.5% and 43.5%,respectively.The MRP-1/CD9 expression was negatively related to the tumor grade (P<0.05),but not to tumor clinical stage (P>0.05).The positive expression rate of HIF-1α was positively correlated with tumor grade and clinical stage (P<0.05) in recurrent tumor. There was no correlation between the positive expression rate of MRP-1/CD9 and HIF-1α(P> 0.05). Conclusion MRP-1/CD9 and HIF-1α expression may be important prognostic indicators for assessing the biological behavior of bladder transitional cell carcinoma.更多还原