【摘要】 目的:探讨胰岛素治疗新生儿高血糖的疗效和安全性。方法:对2002年12月~2005年2月收住院的28例应用胰岛素治疗新生儿重症应激性高血糖患儿的临床资料进行分析,其中男19例,女9例;日龄1 h~7 d,平均日龄16.8 h;日龄<24 h 21例;胎龄29+3~42+2周,早产儿11例,足月儿15例,过期产儿2例。入院时血糖及半小时后复测血糖均在16.80~42.56 mmol/L(300~760 mg/dl),且无下降趋势,平均23.86 mmol/L(426 mg/dl),所有患儿均予正规胰岛素0.1 U/(kg.h)静脉泵入,降低葡萄糖的输注速度为1~2 mg/(kg.min),监测血糖浓度降至8.40 mmol/L(150 mg/dl)以下时停用胰岛素。结果:24例患儿血糖均降至正常,明显下降3例,无效1例;平均用药时间6.1 h;总有效率达96.4%。结论:胰岛素为新生儿重症应激性高血糖安全、有效的治疗药物。更多还原

【Abstract】 Objective:To explore the efficacy and safty of insuline administration to newborns with hyperglycemia.Methods:Twenty-eight neonates with stress hyperglycemia admitted and treated with insuline from Dec.2002 to Feb. 2005 in our hospital were analysed.Among them,19 were male and 9 female,aged 1 hour to 7 days（mean age 16.8 hours） and 21 cases were less than 24 hours old. The gestational age was 29⁺³ to 42⁺² weeks.Eleven premature infants,15 mature infants and 2 postmature infants were enrolled.The Blood Glucose Concentration（BGC） was（16.80）⁴2.56 mmol/L（300～760 mg/dl）[mean BGC 23.86 mmol/L（426 mg/dl）].without showing a decreasing tendency before treatment.All patients received insuline [0.1 U/（kg·h） with micropump] and injection of glucose was reduced [1～2 mg/（kg·min）].Insuline infusing was stoped when BGC was decreased to 8.40 mmol/L（150mg/dl）.Results:The BGC of 24 cases was reduced to normal level,3 cases decreased significantly,though it was still above normal level and 1 case showed inefficient.The average time of insuline treatment was 6.1 hours and the total efficacy was 96.4%.Conclusion:Insuline is a safe and effective drug for treating neonates with severe stress hyperglycemia.更多还原