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氟西汀治疗老年抑郁症的疗效观察

A Comparative Study of Fluoxetine in Elderly Depressive Patients

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【作者】 黄美珍曾为群易敏瘳萍

【Author】 Huang Mei-zhen,Zeng Wei-qun,Yi Min,Liao Ping(Third People′s Hospital of Yichun,Yichun 336000,China)

【机构】 宜春市第三人民医院宜春市第三人民医院 江西宜春336000江西宜春336000

【摘要】 目的:探讨氟西汀治疗老年抑郁症的疗效及安全性。方法:56例老年抑郁症患者随机分为两组:A组和B组,每组各28例。A组采用氟西汀治疗,B组采用阿米替林治疗,两组疗程均为6周。两组疗效评定采用汉密顿抑郁量表(HAMD),两组副反应评定采用副反应量表(TESS)。结果:A组治疗后第2、4、6周末HAMD评分与B组比较,无显著性差异(P>0.05),A组治疗后第2、4、6周末TESS评分明显低于B组(P<0.05)。A组总有效率为78.57%,B组总有效率为71.43%,两组比较,无显著性差异(P>0.05)。结论:氟西汀可作为治疗老年抑郁症的首选药物。

【Abstract】 Objective:To explore the clinical effect and safety of fluoxetine in elderly depression.Methods:Fifty-six patients with elderly depression were double-blind assigned to fluoxetine group and amitriptyline group for 6 weeks.Efficacy was assessed with the Hamilton rating scale for depression(HAMD)and tolerability was assessed from rating scale for adverse effect.Results:Fluoxetine possessed similar efficacy to amitriptyline,the fluoxetine and amitriptyline time of the effect was similar,but the side effects of fluoxetine were slighter than those of amitriptyline.Conclusion:Fluoxetine is effective and safety treatment of elderly depression,and maybe the first choice of drugs for elderly depression.

【关键词】 氟西汀阿米替林抑郁症老年人
【Key words】 fluoxetineamitriptylinedepressionaged
  • 【文献出处】 实用临床医学 ,Practical Clinical Medicine , 编辑部邮箱 ,2006年04期
  • 【分类号】R749.4
  • 【被引频次】1
  • 【下载频次】27
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