【摘要】 目的:探讨CD44V6、EGFR和MMP-9在正常宫颈组织、宫颈上皮内瘤变及宫颈鳞癌组织中的表达及其意义。方法:采用免疫组织化学方法检测20例正常宫颈组织、50例宫颈上皮内瘤变及168例宫颈鳞癌患者组织中的CD44V6、EGFR、MMP-9的水平。结果:CD44V6、EGFR和MMP-9蛋白在宫颈鳞癌组及CIN组中的阳性表达率分别为68.45%、61.90%、70.83%和36.00%、44.00%、34.00%。CD44V6、EGFR和MMP-9的蛋白表达与宫颈鳞癌的临床分期无关(r分别为0.058、0.073、0.005,P均>0.05),但与病理组织学分级、淋巴结转移呈正相关(r分别为0.358、0.269、0.217和0.439、0.338、0.301,P均<0.05)。结论:CD44V6、EGFR和MMP-9可能是宫颈癌发生的相关基因,与肿瘤的发展和转移有关。联合检测CD44V6、EGFR和MMP-9的表达可作为宫颈癌早期诊断、转移潜能和预后的判断。更多还原

【Abstract】 Objective:To investigate the expression of CD44V6、EGFR and MMP-9 in normal cervical tissues,cervical intraepithelial neoplasia(CIN) and squamous cell carcinoma of the cervix and explore its clinical significance.Methods:The expressions of CD44V6、EGFR and MMP-9 in 20 cases of normal cervical tissues,50 cases of CIN and 168 cases of squamous cell cacinoma of the cervix were defected by immunohistochemical technique.Results:The positive rates of expression CD44V6、EGFR and MMP-9 in cervical carcinoma and CIN tissues were 68.45%、(61.90%)、(70.83%) and 36.00%、44.00%、34.00%,respectively.The expression of CD44V6、EGFR and MMP-9 proteins were no relationship with clinical stage(P>0.05),but were all well correlated with pathological grade、lymph node metastasis(P<0.05).Conclusion:CD44V6、EGFR and MMP-9 may be correlated with occurrence,development and metastasis of cervical carcinoma.Examination of the expression of CD44V6、EGFR and mmp-9 may be helpful to the evaluation of metastasis potential and prognosis of early cervical carcinoma.更多还原