【摘要】 目的探讨奎硫平联合碳酸锂治疗急性躁狂发作的疗效及安全性。方法将69例急性躁狂发作患者随机分为两组,研究组34例,对照组35例,两组均在应用碳酸锂治疗的基础上分别联合奎硫平和氯氮平治疗,疗程6w;采用躁狂量表及副作用量表评定临床疗效和不良反应。结果治疗第6w末,研究组总有效率为94.1%、对照组为94.2%,两组总体疗效相当;研究组起效时间稍迟于对照组(P<0.05),不良反应明显少于对照组(P<0.05)。结论奎硫平联合碳酸锂治疗急性躁狂发作疗效肯定、安全性高、依从性好,是治疗急性躁狂发作较好的选择方案。更多还原

【Abstract】 Objective To explore curative effects and safety of quetiapine combined with lithium in acute manic episode. Methods Sixty-nine patients with acute mania(CCMD-3) were randomly assigned to two groups: research group(n=34) receiving quetiapine plus lithium and control group(n=35) clozapine plus lithium for 6 weeks. Curative effectiveness were assessed with Bech-Rafaelsen Mania Rating Scale(BRMS) and side effects with the Treatment Emergent Symptom Scale(TESS).Results After 6 week treatment, total effective rates of the 2 groups were 94.1% and 94.2% respectively and gross curative effects equivalent; compared with control group, research group took effect slightly later(P<0.05) and side effects were significantly fewer(P<0.05).Conclusion Quetiapine plus lithium has better curative effect, higher safety and well compliance and is a better selection in the treatment of acute mania.更多还原