【摘要】 目的研究舍曲林联合心理治疗治疗抑郁、焦虑障碍共病的疗效及安全性。方法将58例抑郁、焦虑障碍共病患者随机分为舍曲林联合心理治疗组和单用舍曲林治疗组各29例进行对照研究,疗程8w,采用汉密顿焦虑量表、汉密顿抑郁量表及药物副作用量表评定临床疗效和不良反应。结果研究组抗焦虑、抗抑郁起效均较对照组快(P<0.05或0.01),抗焦虑疗效优于对照组(P<0.05),治疗8w末两组抗抑郁疗效相当。结论舍曲林联合心理治疗治疗抑郁、焦虑障碍共病起效快,疗效显著,安全性高,依从性好。更多还原

【Abstract】 Objective To study efficacy and safety sertraline plus psychotherapy in the treatment of comorbid depression and anxiety. Methods 58 patients were randomly assigned into the sertraline plus psychotherapy group(n=29) and single sertraline group(n=29) for 8 weeks. Efficacies were assessed with the Hamilton Anxiety Scale(HAMA ) and the Hamilton Depression Scale(HAMD) and side effects with the Treatment Emergent Symptom Scale(TESS). Results Compared with control group, research group took anti-anxiety and -depression effects quicker(P<0.05 or 0.01) and anti-anxious efficacy was better(P<0.05), and anti-depressive efficacy of the 2 groups was equivalent. Conclusion Sertraline plus psychotherapy takes effect quicker and has significant efficacy, higher safety and well compliance in the treatment of comorbid depression and anxiety.更多还原