【摘要】 目的测定靶控输注雷米芬太尼引起呼吸抑制的半数有效血浆浓度(Cp50)。方法20例择期手术病人行椎管内阻滞。按序贯法给予雷米芬太尼靶控输注20min,相邻血浆靶浓度之间比率为1·5。测定RR、SpO2、PETCO2及动脉血气。结果雷米芬太尼引起呼吸抑制的Cp50为1·8μg/L,95%可信区间为1·5~2·1μg/L。结论雷米芬太尼引起呼吸抑制的Cp50为1·8μg/L。更多还原

【Abstract】 Objective To determine the half-effective target plasma concentration （Cp 50 ） of remifentanil to cause respiratory depression. Methods Twenty patients undergoing elective operations were enrolled. Intrathecal block was given. TCI remifentanil was given by “up and down” method for 20min, and the ratio of two close plasma concentrations was 1.5. RR, SpO₂, P ET CO₂ and arterial gas analysis were measured. Results The CP 50 of remifentanil was 1.8 μg/L. The 95% confidence level was 1.5-2.1μg/L. Conclusion The half-effective target plasma concentration of remifentanil to cause respiratory depression was 1.8μg/L.更多还原