【摘要】 目的测定犬静脉注射乳化异氟醚的最低肺泡有效浓度(MAC静脉),并与吸入异氟醚麻醉时的最低肺泡有效浓度(MAC吸入)进行比较。方法将40只杂种犬平均分成静脉和吸入麻醉两组。应用序贯法和自身交叉法同时测定犬的MAC值。结果静脉组序贯法所测得的MAC静脉(0.94±0.10)%,与自身交叉法所测得的前6个交叉点的MAC静脉(0.89±0.14)%或全部交叉点的MAC静脉(0.93±0.13)%之间差异均无显著意义(P>0.05)。吸入组序贯法所测得的MAC吸入(1.29±0.10)%,与自身交叉法所测得的前6个交叉点的MAC吸入(1.24±0.06)%或全部交叉点的MAC吸入(1.33±0.09)%之间差异亦无显著意义(P>0.05)。但两组间比较MAC静脉均小于MAC吸入,差异有显著意义(P<0.05)。结论乳化异氟醚静脉麻醉时的MAC静脉明显小于吸入异氟醚麻醉时的MAC吸入,序贯法和自身交叉法对MAC的测定结果无明显影响。更多还原

【Abstract】 Objective To determine the minimum alveolar concentration(MAC_iv) of intravenous emulsified isoflurane and compare it with the minimum alveolar concentration(MAC_inh) by isoflurane inhalation in dogs.Methods Forty healthy adult mongrel dogs were equally assigned to（intravenous） anesthesia group with emulsified isoflurane（8%,vol/vol） and inhalation anesthesia group with isoflurane vapor.In each group sequential method and self-crossover method were simultaneously applied to determine MAC_iv and MAC_inh.Results In intravenous anesthesia group,the MAC_iv determined by sequential method and the MAC_ivs of previous 6 crossover points and all crossover points（determined） by self-crossover method were（0.94±0.10）%,（0.89±0.14）% and（0.93±0.13）%,（respectively.） No significant difference was found between them（P>0.05）.In inhalation anesthesia group,the MAC_inh determined by sequential method and the MAC_inhs of previous 6 crossover points and all crossover points determined by self-crossover method were（1.29±0.10）%,（1.24±0.06）% and （1.33±0.09）%,respectively.No significant difference was found between them.But MAC_iv was significantly smaller than MAC_inh between the two groups（P<0.05）.Conclusion MAC_iv of emulsified isoflurane was significantly smaller than MAC_inh of isoflurane.The determined values of MAC_iv and MAC_inh were not remarkably affected by determined methods.更多还原