【摘要】 目的观察托烷司琼用于曲马多术后静脉自控镇痛相关恶心呕吐的防治作用。方法择期上腹部手术且接受术后曲马多静脉自控镇痛病人90例,ASAⅠ~Ⅱ级,随机分为三组,每组30例。Ⅰ组,托烷司琼组;Ⅱ组,胃复安组;Ⅲ组,生理盐水对照组。观察各组术后1、4、8、12、24 h时的恶心呕吐评分、镇静评分和口渴分级。结果Ⅰ、Ⅱ组术后4、8、12、24 h时恶心呕吐发生率显著低于Ⅲ组(P<0.05或P<0.01);同时在术后12、24 h时Ⅰ组效果优于Ⅱ组(P<0.05);三组间口渴分级和镇静评分差异无显著意义。结论托烷司琼对于曲马多术后静脉自控镇痛所引起的恶心呕吐有较好防治作用,其镇吐效果优于胃复安。更多还原

【Abstract】 Objective To investigate the effects of tropisetron on postoperative nausea and vomiting(PONV) during patient-controlled intravenous analgesia(PCIA) with tramadol in patients undergoing upper abdominal operation.Methods Ninety ASAⅠ-Ⅱpatients undergoing selective(upper) abdominal surgery were randomly divided into three groups with 30 cases each.GroupⅠwas given tropisetron 5mg plus tramadol 1500mg,groupⅡ metoclopramide 20mg plus tramadol(1500mg) and group Ⅲ tramadol(1500mg.) Postoperative nausea and vomiting,sedation and thirst scores were (observed) at 1,4,8,12 and 24h after operation.Results The incidences of PONV in groupⅠand Ⅱwere significantly lower than those in group Ⅲ at 4,8,12 and 24h postoperatively(P<0.01 or P<0.05).The incidence of PONV in groupⅠwas significantly lower than that in groupⅡat 12 and 24h postoperatively(P<0.05).There were no differences among the three groups in thirst scores at the same time points.Sedation scores of all groups were similar at all the measured times.Conclusion Tropisetron can decrease the incidence of PONV during PCIA with tramadol,which is better than(metoclopramide.)更多还原