【摘要】 目的：探讨尿微卫星不稳定性改变(MSI)与膀胱移行细胞癌(TCC)临床病理特征的关系及其在早期诊断中的价值。方法：选择36例TCC患者5个微卫星位点,应用聚合酶链反应-变性聚丙烯酰胺凝胶银染法分析尿微卫星的改变。结果：36例中有22例(61．11%)出现微卫星不稳定性改变(LOH/MSI),并与肿瘤的分期、分级无关(P＞0．05)；尿脱落细胞学检查的阳性率为22．22%(8/36),两者相比差异有统计学意义(P＜0．05)。结论：尿沉渣微卫星不稳定性分析对膀胱癌的早期诊断有一定的意义,是尿脱落细胞学检查的重要补充。所选微卫星位点为本地区膀胱癌的进一步研究奠定了基础。更多还原

【Abstract】 Objective To investigate the microsatellite instability in transform cull carcinoma of the bladder and their relationship with the clinical and pathological character,evaluate its wdue in diagnose and prognosis.Meth- ods:5 microsatellite markers were selected to examine 36 TCC patients with PCR and their change was analysed. Results:Microsatellite instability changing was found in 29 of 36 patients(80.56%),and there is no relation be- tween the tumor grade and tumor stage(P＞0.05);compared with 22.22%,the positive rate of the urine shed off(8/36),there is significant difference(P＜0.05).Conclusions:There is some value in the analysis of the micro satellite instability in urine dregs to diagnose of bladder tumor in forepart,it can be important makeup to checking of urine shed,the selected microsatellite markers have built important basis for the more research of bladder tumor.更多还原