【摘要】 目的探讨和分析冠心病合并2型糖尿病患者的临床特点。方法对20名正常人(正常组)、138例单纯冠心病(冠心病组)、56例冠心病合并2型糖尿病(冠心病合并糖尿病组)三组患者进行临床症状、冠脉病变、血糖(BS)、血脂、C-反应蛋白(CRP)和纤维蛋白原(Fib)比较。结果(1)与冠心病组比较,冠心病合并糖尿病组患者临床症状不典型,以无痛性心肌缺血和心功能不全居多。(2)与冠心病组比较,冠心病合并糖尿病组患者多支、C型和末梢病变发生率明显增高,冠脉狭窄和钙化程度严重。(3)与冠心病组和正常组比较,冠心病合并糖尿病组CRP、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、Fib显著增高,高密度脂蛋白胆固醇(HDL-C)显著降低。结论冠心病合并2型糖尿病患者,易发生心功能不全,冠脉病变严重;血脂异常和炎症反应共同促进动脉粥样硬化的发生和发展。更多还原

【Abstract】 Objective To explore and analyze clinical characteristics of coronary disease complicated with diabetes mellitus.Methods 20 normal person(group NP),138 coronary heart disease patient (group CHD) and 56 coronary disease and type-2 diabetes mellitus patient(group CHD-DM) were compared for clinical symptoms,coronary lesion and blood sugar,blood lipid,C reactive protein(CRP) and fibrinogen(Fib).Result (1)compared with group CHD,group CHD-DM has atypical symptoms and more silent heart ischemia and heart failure;(2)compared with group CHD,group CHD-DM has more peripheral type C lesion and in distal end of the coronary artery as is sever of the extent of coronary stenosis and coronary calcified plaque;(3)compared with group NP、group CHD,group CHD-DM has higher CRP,TG,LDL-C and Fib,but lower HDL-C.Conclusions Coronary heart disease complicated with diabetes mellitus tenders to develop heart failure,severe coronary lesion;abnormal blood lipids and inflammation promote the development of atherosclerosis.更多还原