【摘要】 目的:探讨西酞普兰治疗老年期抑郁症的临床疗效及安全性。方法:将60例老年期抑郁症患者随机分为西酞普兰组及阿米替林组(各30例)。西酞普兰治疗剂量为20~40 mg/d,阿米替林为100~250 mg/d。疗程6周。疗效评定采用Hamilton抑郁量表(HAMD),安全性评价应用副反应量表(TESS)及实验室检查。结果:西酞普兰组显效率为77%,有效率为92%,与阿米替林组的70%及90%相当;西酞普兰组不良反应较阿米替林组少且轻微。结论:西酞普兰与阿米替林对老年期抑郁症均有较好的疗效,但西酞普兰具有服用简便,不良反应轻等优点。更多还原

【Abstract】 Objective:To investigate the clinical efficacy and adverse reaction of citalopram in the treatment of patients with senile depression.Method:60 patients with senile depression were divided into two groups.The citalopram group of 30 patients was treatment with citalopram 20-40 mg/d.The amitriptyline group of 30 patients was treatment with amitriptyline 100-250 mg/d.All patients were observed for 6 weeks.The efficacy was evaluated by Hamilton depressive scale(HAMD),safety was evaluated by treatment emergant sympton scale(TESS) and laboratory examination.Results:After 6 weeks treatment,the significant improvement rate and response rate of citalopram group was 77% and 92% respectively.The significant improvement rate and response rate of amitriptyline group was 70% and 90% respectively.There were no significant differences between two groups.However the adverse reactions that occoured more often and severer with amitriptyline than citalopram. Conclusion:The results indicate that both citalopram and amitriptyline are effective in the treatment of patients with senile depression,but citalopram shows more advantages for its convenient administration and fewer adverse reaction.更多还原