【摘要】 目的:比较利培酮、氯氮平和氯丙嗪分别合并碳酸锂治疗急性躁狂的疗效和安全性。方法:将符合中国精神障碍分类与诊断标准第3版诊断标准的各型躁狂患者随机分为3组,在使用碳酸锂的同时分别联合利培酮、氯氮平或氯丙嗪进行为期8周的治疗。用躁狂评定量表(MRS)评定疗效,副反应量表(TESS)评定不良反应。结果:利培酮合并碳酸锂治疗急性躁狂的疗效与氯氮平或氯丙嗪合并碳酸锂相近,不良反应轻于氯氮平组和氯丙嗪组,但其起效时间迟于氯氮平组,与氯丙嗪组相似。结论:利培酮合并碳酸锂治疗急性躁狂疗效较好,安全性高,可作为治疗急性躁狂的一个选择。更多还原

【Abstract】 Objective:To compare the efficacy and safety of risperidone,clozapine and chlopiomazine combined with lithium in acute mania respectively. Method:All patients with acute mania according to CCMD- 3 were randomly assigned to receive risperidone,clozapine or chlopiomazine respectively and all of them combined with lithium.The study lasted for 8 weeks.The efficacy and safety were evaluated with mania rating scale (MRS) and treatment emergant symptom scale (TESS) respectively. Results:The efficacy of resperidone group was similar to the other groups and had less side effects.Resperidone group took effect more slowly than clozapine group,but was similar to chlopromazine group. Conclusion:The efficacy and safety of risperidone combined with lithium are higher in acute mania.It may be a good choice in the treatment of acute mania.更多还原