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脂肪肝脂质过氧化与细胞因子TNF-α、IGF-1水平的临床观察

Clinical study of the relationship about fatty liver lipid peroxides with tumor necrosis factor α and insulin-likegrowth factorl.

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【作者】 黄妙珍

【Author】 HUANG Miao-zhen(Hangzhou second people’s hospital,Hangzhou 310015)

【机构】 杭州师范学院附属医院 浙江杭州310015

【摘要】 探讨脂肪肝的脂质过氧化与细胞因子的相关性。选择64例脂肪肝患者,测定血清中丙二醛(m alond i-aldehyde,MDA)、超氧化物歧化酶(superoxide d ismutase,SOD)、肿瘤坏死因子α(tumor necrosis factor,αTNF-α)、胰岛素样生长因子1(insu lin-likegrowth factor 1,IGF-1)的水平,并选择56例非脂肪肝的健康人为正常对照。结果显示脂肪肝患者MDA和TNF-α水平升高,与正常组比均为(P<0.05);SOD和IGF-1水平下降,与正常组比分别为(P<0.05,P<0.01)。提示脂肪肝患者存在脂质过氧化,与TNF-α和IGF-1存在相关性。

【Abstract】 To observe as study group the relationship about fatty liver lipid peroxides and cell factor.64 fatty liver cases were selected,the level of MDA、SOD、TNF-α and IGF-1 were tested.56 healthy cases were as contral group.The results demonstrated that the level of MDA and TNF-α were higher,than that of control group(P<0.05,respectively);while the l evel of SOD and IGF-1 were lower,than that of control group(P<0.05,P<0.01,respectively).The study shows that fatty liver exists lipid peroxides and was related to TNF-α and IGF-1.

  • 【文献出处】 临床肝胆病杂志 ,Chinese Journal of Clinical Hepatology , 编辑部邮箱 ,2006年03期
  • 【分类号】R575.5
  • 【被引频次】2
  • 【下载频次】109
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