【摘要】 研究肝细胞肝癌(Hepatocellu lar Carc inom a,HCC)微血管密度(M icrovessel Density,MVD)与雌激素受体(Estrogen Receptor,ER)表达之间的关系,以及此二者与临床病理学特征之间的关系。36例HCC的患者分为ER(+)组和ER(-)组。按MVD值分为MVD<中位值组和MVD>中位值组,比较各组有预后意义的临床病理学参数之间的差别。ER(+)14例,ER(-)22例。全组MVD自3至121(44.67±32.15中位值为36)。ER(+)的HCC为直径较小、多有完整的包膜和较低的血清AFP浓度。MVD较低的HCC多为单结节、直径较小、细胞分化较好、血清AFP浓度较低。ER含量与MVD呈负相关。由此可见:(1)ER(+)或MVD较低的HCC分别比ER(-)或MVD较高的HCC恶性度较低。(2)ER与MVD均是有价值的预后指标。更多还原

【Abstract】 To explore the relationship between intra tumoral microvessel density and estrogen receptor expression in hepatocellular carcinoma,and their relationship with the prognostic factors.36 patients with HCC were disparted into two groups: ER negative group and ER positive group.According to MVD value,they were disparted into MVD<median group and MVD>median group,and the established prognostic factors were compared.There were 14 ER(+) and 22 ER(-)cases,MVD value ranged from 3 to 121(44.67±32.15 median=36).Significant associations were found between ER status and tumor size,encapsulation and serum AFP concentration.Significant associations were found between MVD and the number of nodules,tumor size,Edmonson-Steiner class and serum AFP concentration.Inverse association was found between ER status and MVD.This shows:(1)ER positive or lower MVD in HCC has lesser malignant biological behavior than ER negative or higher MVD in HCC respectively.(2)Both ER status and MVD are good prognostic factors.更多还原