【摘要】 探讨小儿慢性乙型肝炎(CHB)细胞因子IL-12和INFγ与HBV DNA定量及HBVM的关系及意义。46例慢性乙型肝炎患儿和30例健康儿童均分别以ELISA法检测IL-12和IFNγ及HBVM,以荧光定量PCR法检测HBV DNA。HBeAg阴性组IL-12和IFNγ较HBeAg阳性组明显升高(P值均<0.05)。高病毒载量组IL-12和IFNγ水平均显著高于对照组(P值均<0.01)。慢性乙型肝炎患儿IL-12和IFNγ与HBeAg及HBV DNA水平密切相关。更多还原

【Abstract】 To investigate the serum levels of IL-12、IFNγ,quantitative HBV DNA,HBVM,and their sense in children with chronic hepatis B(CHB).The serum IL-12、 IFNγ and HBVM,HBV DNA of 46 CHB patients were measured by specific-ELISA and PCR respectively 30 healthy children were employed as the control.The serum levels of IL-12、 IFNγ in HBeAg negative CHB were higher than those in HBeAg positive CHB patients(P<0.05).The serum levels of IL-12、 IFNγ of high virus load group were significantly higher than those in the control(P<0.01).IL-12 and IFNγ of children with CHB closely correlate with the HBeAg and HBV DNA.更多还原