【摘要】 目的了解河北南部多中心3 141例肾活检资料的流行病学特点及病理类型与临床表现之间的联系。方法回顾性分析1999年5月至2006年1月3 141例因肾脏疾病而行肾活检患者的性别、年龄、病理类型及临床表现。结果本组患者做肾活检时的年龄6~82岁,平均(33.8±12.7)岁;男1 670例(52.3%),女1 471例(46.8%)。11~49岁患者2 544例(81%)。大多数肾脏疾病男性占优势,而狼疮性肾炎(LN)、原发性小血管炎肾损害、肾小管间质疾病(TID)女性占优势。最常见的病理类型依次为慢性肾炎综合征(IgAN)(26.0%)、微小病变(MCD)(13.2%)、膜性肾病(MN)(10.8%)、LN(7.0%)、紫癜性肾炎(HSPN)(6.8%);平均年龄分别为(30.7±11.4)岁、(31.3±6.2)岁、(40.5±8)岁、(32.8±9.9)岁(、26.9±9.8)岁。最常见的临床综合征是慢性肾炎综合征(CNS)(43.8%)和肾病综合征(NS)(42.2%)。CNS最常见的病理类型是IgAN(49.1%)、HSPN(15.6%)、MN(9.5%)。NS最常见的病理类型为MCD(32.0%)、MN(17.5%)、LN(15.5%)。结论最常见的肾小球疾病是IgAN,男性,青壮年是高发人群,最常见的临床表现是CNS。更多还原

【Abstract】 Ojective To survey the clinical epidemiology and correlations between pathology and clinical features of a major groups of kidney diseases.Methods From May 1999 to January 2006,histological diagnosis of renal disease was made in 3141 patients from multiple centers of south region in Hebei Province(Hebei,China).Demographic data were obtained from all patients,and the clinical profiles were analyzed in(2 662) patiants.Results The mean age of the whole groups was((33.8)±(12.7)) (6-82) years old.The male cases accounted for(53.2%)((1 670) cases) and female(43.5)%((46.8)%).The groups of 11-49 years patients ere up to 81%((2 544) cases).Males were predominant in most renal diseases,females were predominant in lupus nephritis(LN),and tubular interstitial disease.IgA nephropaty(IgAN) was the most frequent pathological pattern((26.0)%),followed by minimal change disease(MCD)((13.2)%),membranous nephropathy(MN)((10.8)%),LN((7.0)%),Henoch-Schonlein purpura nephritis(HSPN)((6.8)%).Their mean age were((30.7)±(11.4)),((31.3)±(6.2)),((40.5)±(8.3)),((29.8)±(9.9)),((26.9)±(9.8)) years old respectively.The most common clinical syndrome was chronic nephritic syndrome(CNS)((43.8)%),followed by nephrotic syndrome(NS)((42.2)%).IgAN((49.1)%),HSPN((15.6)%) and MN((9.5)%) were the most frequent diagnoses in patients with CNS.MCD((32.0)%),MN((17.5)%),LN((15.5)%)were the most frequent diagnoses in NS.Conclusion IgAN was the most common renal disease.Male,adolescentce are predominant in this group of patients.The most common clinical syndrome is CNS.更多还原