【摘要】 目的应用典则相关分析探讨急性心肌梗死合并室壁瘤形成患者血浆肌钙蛋白I(TnI)、脑钠素(BNP)、白介素-8(IL-8)与心室收缩功能、舒张功能、收缩同步性的相关性。方法84例首次急性前壁心肌梗死且左室造影证实存在室壁瘤形成的患者,胸痛发作12小时测定TnI、BNPI、L-8。入院后第1周应用平衡法核素心室造影(ERNA)测定左室收缩功能(LVSF)、舒张功能(LVDF)、收缩同步性功能(LVSS)各参数。应用典则相关分析,分析TnI、BNP、IL-8与LVSF、LVDF、LVSS的相关性。结果3对典则变量的典则相关系数分别为0.769253(P=0.0373)、0.662367(P=0.0418)、0.331153(P=0.382),第1对(V1,W1)、第2对(V2,W2)典则变量共代表了94.77%的相关信息。从标准化典则相关系数可知,V1典则变量主要反映了BNP、IL-8,W1主要反映了峰相位标准差(PSD)、峰驻盈时间(TPFR)、峰充盈率(PFR)。TnII、L-8、BNP与PSD、TPFR呈正相关,与PFR呈负相关。V2典则变量主要反映TnI,W2主要反映LVEF、半高宽(FWHM)。TnI与FWHM呈正相关,与LVEF呈负相关。结论血浆TnI、IL-8、BNP升高可以作为急性心肌梗死合并室壁瘤形成患者心室收缩功能、舒张功能、收缩同步性降低的预测因子。更多还原

【Abstract】 Objective To investigate the relationship between plasma troponin I（TnI）,brain natriuretic peptide（BNP） interleukin-8（IL-8） and ventricular systolic diastolic,systolic,synchronization function by the canonical correlation analysis in the patients with acute myocardial infarction（AMI） accompanied with left ventricular aneurysm.Methods Eighty-four patients with first AMI of anterior wall and left ventricular aneurysm formation by left ventriculography examination were included.Plasma TnI,BNP and IL-8 were measured at 12 hours after onset of AMI.At first week of AMI,the parameters such as left ventricular systolic function（LVSF）,left ventricular diastolic function（LVDF） and left ventricular systolic synchronization（LVSS） systolic synchronization function were measured by equilibrium radionuclide angiography（ERNA）.The relationship between TnI,BNP,IL-8 and heart function parameters was evaluated by the canonical correlation analysis.Results The three pairs of canonical coefficients were（0.769253）（P=（0.0373））,（0.662367）（P=（0.0418））,（0.331153）（P=（0.382））,respectively.The first（V₁,W₁） and second（V₂,W₂） pairs of canonical variables summarized（94.77）% correlation information.From the standard correlation coefficients,V₁ variable reflected BNP,IL-8 dominantly,while W₁ reflected the peak phase standard deviation（PSD）,time to peak filling rate（TPFR）,peak filling rate（PFR） dominantly.TnI,IL-8,BNP were positive correlated with PSD,TPFR,but significantly negative correlated with PFR.V₂ reflected TnI,while W₂ reflected LVEF and full wilth at half maximun（FWHM） dominantly.TnI was positive correlated with FWHM,but negative correlated with LVEF.Conclusion Increase of plasma IL-8,BNP and TnI could be predictors for the reduction of LVSF,LVDF and LVSS in the patients with AMI accompanied with left ventricular aneurysm.更多还原