【摘要】 研究5-fu胃粘附片,采用自制的粘附力测定装置,考察并比较不同处方的粘附力大小,同时考察了粘附片的体外溶胀百分率。结果表明,辅料比例不同,不同处方粘附片的粘附力不同,溶胀百分率不同。粘附力大小和溶张百分率都可以作为胃粘附片的体外评价参考指标。更多还原

【Abstract】 Study on bioadhesion of 5-fluorouracil gastric bioadhesive tablets is the main aim. The bioadhesive force was evaluated by a self-made apparatus, and compared the force of the different formulations. In the same time, the content of swelling and expansion of tablets were also studied. The findings show that the bioadhesion force and the content of swelling and expansion of tablets were different from various formulations. The bioadhesion force, content of swelling and expansion of tablets also were criterions as the reference.更多还原