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开胸结扎猪冠状动脉建立急性心肌梗死动物模型的研究

Experimental Model of Acute Myocardial Infarction Induced by Ligation of Coronary Artery in Swines

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【作者】 孙林熊国昌光雪峰李易阮志敏杨锋

【Author】 SUN Lin 1),XIONG Guo-chang 2),GUANG Xue-feng 1),LI Yi 3),RUAN Zhi-min 1),YANG Feng 3) (1)Dept. of Cardiology, The 2nd Affiliated Hospital of Kunming Medical College, Kunming 650101; 2) Dept. of Cardiology, The 1st People’s Hospital of Kunming, Kunming 650031; 3) Cardiac Center, The 2nd People’s Hospital of Yunnan Province, Kunming 650021,China)

【机构】 昆明医学院第二附属医院心血管内科昆明市第一人民医院心血管内科云南省第二人民医院心脏中心内科 云南省冠心病基础研究室昆明650101昆明650031云南省冠心病基础研究室昆明650021

【摘要】 目的建立猪急性心肌梗死模型.方法无菌条件下开胸结扎猪冠状动脉左回旋支(LCX),建立急性心肌梗死动物模型.结果LCX结扎术后心电图、心肌酶学改变及选择性冠脉造影证实猪急性心肌梗死模型制作成功.结论冠脉结扎法是一种有效可行的制备急性心肌梗死模型的方法.

【Abstract】 Objective To establish an experimental animal model of acute myocardial infarction (AMI) in the swine. Methods Under sterilization, the swine’s chest was cut open and the left circumflex coronary artery (LCX) was ligated.Results After the operation, the changes of Electrocardiogram (ECG) and myocardial-enzymes in the blood serum and selective coronary angiography all proved that the animal model of AMI in the swine was successful. Conclusions Ligating coronary was a valuable method to make an animal model of AMI.

【关键词】 心肌梗死动物模型
【Key words】 Myocardial infarctionExperimental animal modelSwine
【基金】 云南省自然科学基金资助项目(2000C0109M)
  • 【文献出处】 昆明医学院学报 ,Journal of Kunming Medical College , 编辑部邮箱 ,2006年03期
  • 【分类号】R-332
  • 【被引频次】11
  • 【下载频次】182
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