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基于基因表达谱的结肠癌特征基因选取
Informative Genes Selection for Colon Tumor Based on Gene Expression Profiles
【摘要】 在分析肿瘤基因表达谱的基础上,运用模式识别方法选取结肠癌特征基因.利用浮动顺序搜索算法在结肠癌基因表达谱数据中生成若干个候选特征基因子集,再以RBF支持向量机作分类器,以其在训练集和测试集中的错误分类率为依据,从候选特征基因子集中选取结肠癌特征基因集合.实验结果表明了该方法的可行性和有效性.
【Abstract】 Gene expression profiles of tumor and select colon tumor feature subsets are analyzed by means of pattern recognition.Firstly,the "Floating Sequential Search Algorithm" is used to generate candidate feature subsets from gene expression profiles.Secondly,a support vector machine is employed to classify the samples.The feature subsets with a minimum error are chosen as a set of colon informative gene.The result proves that the tissue samples can be classified with high correctness and the proposed approach is effective and feasible.
【关键词】 支持向量机;
基因表达谱;
肿瘤基因;
【Key words】 support vector machine; gene expression profiles; tumor genes;
【Key words】 support vector machine; gene expression profiles; tumor genes;
【基金】 国家自然科学基金重点资助项目(项目编号:60234020)
- 【文献出处】 昆明理工大学学报(理工版) ,Journal of Kunming University of Science and Technology(Science and Technology) , 编辑部邮箱 ,2006年01期
- 【分类号】R735.35
- 【被引频次】5
- 【下载频次】315