【摘要】 目的比较分析我院2003-2005年与2000—2002年耐亚胺培南铜绿假单胞菌的发生率及对其他抗菌药物的耐药性变迁。方法收集我院自2000年1月—2005年12月细菌室分离的铜绿假单胞菌,采用琼脂扩散法进行药敏试验。结果2003—2005年间细菌对亚胺培南耐药率为26.5%(160/604),2000—2002年间耐药率为34.4%(175/508,与2003—2005年比较差异有显著性,P<0.01)。痰标本中分离的耐亚胺培南铜绿假单胞菌在2003—2005年与2000—2002年均占较大比例,分别为75.0%(120/160)和69.1%(121/175),其次为尿液(分别为6.9%和11.4%)和伤口分泌物(5.0%和4.0%)。2003—2005年与2000—2002年耐亚胺培南铜绿假单胞菌对β内酰胺类、喹诺酮类和氨基苷类均耐药。但2003—2005年对庆大霉素和头孢哌酮—舒巴坦的耐药性较2000—2002年显著下降(P<0.01)。结论碳青霉烯耐药性铜绿假单胞菌的发生率2003—2005年较2000—2002年下降,并且对多种抗菌药物的耐药性有所下降,进一步提醒临床医师合理直用抗菌药物的重要性。更多还原

【Abstract】 Objective To compare the changing pattern and resistance of imipenem resistant Pseudomonas aeruginosa(IRPA) in 2003—2005 with that in 2000—2002.Methods Strains of P.aeruginosa isolates between January 2000 and December 2005 were collected.Antimicrobial susceptibility of clinical isolates was tested by Kirby-Bauer method.Results The prevalence of IRPA was 26.5%(160/604)in 2003—2005 which was significantly lower than that in 2000—2002(34.4%.175/508.P<0. 01).IRPA was mostly isolated from sputum during 2003—2005 and 2000—2002,which accounted for 75.0%(120/160)and 69.1%(121/175),followed by urine(6.9% and 11.4%.respectively),wound secretion(5.0% and 4.0%.respectively). etc.IRPA was also resistant to other β-lactams.fluoroquinolones and aminoglycosides.The strains resistant to gentamicin and cefoperazone-sulbactam tended to decrease in 2003—2005 compared with that in 2000—2002(P<0.01).Conclusions The prevalence of IRPA and resistance rate to some other antibiotics tended to decrease,indicating the importance of appropriate an- tibiotics selection.更多还原