【摘要】 目的:观察补阳还五方对急性心肌梗死的保护作用,比较其醇提物与水提物的作用差异。方法:将麻醉犬冠状动脉结扎造成心肌梗死模型,设补阳还五方醇提物低、高剂量组(20、40 g/kg),补阳还五方水提物低、高剂量组(20、40 g/kg),假手术组及模型对照组,以心电图ST段、血清LDH、CK、SOD和MDA、心肌梗死范围为评价指标。结果:补阳还五方醇提物及水提物均可对抗心电图ST段上移,降低血清LDH、CK及MDA,升高SOD,减少心肌梗死面积,但与原药材相当的醇提物活性明显强于水提物(P<0.01)。结论:补阳还五方对犬冠脉结扎造成的急性心肌梗死有保护作用,其醇提物优于水提物。更多还原

【Abstract】 Objective: To observe protective action of Buyanghuanwu prescription(BP) on acute myocardial infarction and to compare the different effects between its alcohol extract(AE) and water extract(WE).Methods: Myocardial infarction model was made by ligating coronary artery in anesthetized dog,the experiment was consistent of sham operation group,myocardial infarction group,low and high dose groups of alcohol extract (20、40 g/kg respectively),and low and high dose groups of water extract(20、40 g/kg respectively).The results were evaluated by serum levels of LDH、CK、SOD 、MDA,the STsegment elevation in ECG and myocardial infarct size.Results: AE and WE could both prevent STsegment shifting,reduce serum levels of LDH、CK、MDA,increase serum SOD and decrease myocardial infarction area,but at the same dose of crude drugs,AE was better than WE in effect.Conclusion: BP has protective effect on myocardial infarction caused by ligating coronary artery in anesthetized dog,its AE is superior to WE in effect.更多还原