【摘要】 目的对清脑宣窍方有效部位化学成分进行系统研究。方法大孔树脂、聚酰胺、硅胶等色谱方法分离,波谱法鉴定结构。结果从清脑宣窍方有效部位中分离得到12个化合物,分别为20(S)-原人参三醇(Ⅰ),人参皂苷Rd(Ⅱ),三七皂苷R4(Ⅲ),2,α3,β19,α23-四羟基齐墩果-12-烯-28-酸(Ⅳ),6″-香豆酰龙胆双糖苷(Ⅴ),Galioside(Ⅵ),6α-Hydroxygeniposide(Ⅶ),槲皮素(Ⅷ),3,3’,5,5’-四甲氧基-4,4’-二-β-D-葡萄糖双环氧木脂素(Ⅸ),藏红花酸(Ⅹ),豆甾醇(Ⅺ)和β-谷甾醇(Ⅻ)。结论均为首次从清脑宣窍方有效部位中分离得到的已知化合物。更多还原

【Abstract】 Objective To study systemically the chemical components from the effective fraction of(Qingnaoxuanqiao) Formula.Methods The isolation were carried out by the chromatographic methods of macro-reticular resin,polyamide and silica gel.The structure was identified with spectroscopy method.Result There were 12 chemical components isolated from the effective fraction of Qingnaoxuanqiao(Formula) respectively,including ①20(S)-protopanaxatriol,②gensenoside-Rd,③notogensenoside-R4,④2α,3β,19α,23-tetrahydroxy olean-12en-28-oic acid,⑤6``-O-p-coumaroyl genipin-gentiobioside,(⑥Galioside),⑦6α-Hydroxygeniposide,⑧quercetin,⑨3,3’,5,5’-tetramethoxy-4,4’-di-β-D-gluco(pyranosyl) lignan,⑩Crocetin,B11stigmastanol,and B12β-sitosterol.Conclusion All these 12 chemical components,as known compounds,are isolated for the first time from the effective fraction of(Qingnaoxuanqiao) Formula.更多还原