【摘要】 目的探讨川芎配伍不同比例的郁金对阿魏酸在家兔体内的药代动力学的影响。方法采用高效液相色谱法,3P97药物代谢动力学软件拟合药动学模型,采用方差分析和SNK检验方法统计处理。结果川芎单煎组、川芎郁金1∶1和1∶2组中阿魏酸在兔体内的动力学行为均符合二室模型,各组的药代动力学主要参数分别为：吸收半衰期为(1．867±0．602)、(3．369±2．746)、(5．751±3．657)min,分布半衰期为(25．944±10．536)、(19．234±3．603)、(22．120±6．774)min,消除半衰期为(1029．501±510．000)、(1221．933±260．307)、(977．542±363．250)min,血药浓度时间曲线下面积为(740．197±978．625)、(697．046±466．889)、(711．389±619．103)mg/(L·min),CL(s)为(0．014±0．007)、(0．014±0．007)、(0．017±0．009)mL/min,T(peak)为(8．479±4．112)、(11．633±6．227)、(18．349±5．928)min,最高血药浓度为(3．916±1．404)、(4．713±1．926)、(2．782±1．581)mg/L。结论川芎配伍不同比例的郁金后,阿魏酸在家兔体内的动力学过程整体上均符合二室模型。川芎配伍一定比例的郁金时,有利于阿魏酸在家兔体内的转运；而郁金用量较大时会使阿魏酸的吸收减慢,为临床用药提供参考依据。更多还原

【Abstract】 Objective To investigate the effects of Szechwan Lovage Phizome combined with different proportions of Turmeric Root Tuber on the pharmacokinetics of ferulic acid(FA)in rabbits.Methods HPLC,3P97 pharmacokinetic program and model,analysis of variance(ANOVA)and student-new man- keuls(SNK)test were used for total statistics and analysis.Results The pharmacokinetic behaviors of FA in rabbits were fitted two-compartment model in group 1(with Szechwan Lovage Phizome only), group 2(Szechwan Lovage Phizome and Turmeric Root Tuber in a ratio of 1:1)and group 3(Szechwan Lovage Phizome amd Turmeric Root Tuber in a ratio of 1:2).The main parameters in 3 groups respectively were:T1/2Ka=1.867±0.602,3.369±2.746 and 5.751±3.657min,T1/2α= 25.944±10.536,19.234±3.603 and 22.120±6.774min,T1/2β=1029.501±510.000,1221.933±260.307 and 977.542±363.25min,AUC=740.197±978.625,697.046±466.889 and 711.389±619.103mg/L·min,CL(s)=0.014±0.007,0.014±0.007 and 0.017±0.009mL/min,T (peak)=8.479±4.112,11.633±6.227 and 18.349±5.928min,C(max)=3.916±1.404, 4.713±1.926 and 2.782±1.581mg/L.Conclusion Szechwan Lovage Phizome combined with different proportions of Turmeric Root Tuber was totally fitted to two-compartment model in the pharmacokinetie procedure.Szechwan Lovage Phizome combined with an appropriate proportion of Turmeric Root Tuber has an improvement effect on the transport of FA in rabbits,while FA will be absorbed slowly when Turmeric Root Tuber is used excessively.It is an important reference for the clinical application of Szechwan Lovage Phizome and Turmeric Root Tuber.更多还原