【摘要】 目的:观察肝移植患者围手术期及急性排斥反应时血清可溶性血小板T细胞活化抗原1(sPTA1,CD226)水平与排斥反应的相关性。方法:用夹心ELISA法测定肝移植患者血清sPTA1水平。结果:25例尸体肝移植患者中经病理证实的排斥反应发生时sPTA1显著升高,经加强免疫抑制剂治疗后,血清sPTA1下降,且sPTA1水平的变化早于临床症状表现。结论:PTA1是一项较为可靠的判别和监测急性排斥反应的指标,与病理检查的结果有较好的一致性,可以作为移植物急性排斥反应的监测和预警指标。更多还原

【Abstract】 Objective:To study the interrelationship between serum sPTA1 level and allograft acute rejection in liver transplantation.Methods:Solid-phase ligand ELISA method was used to analyzed serum of sPTA1 in liver transplantation.(Results: when) two cases of 25 after liver transplantation patients were distinguished as allograft acute rejection by pathologic(examination),the level of serum sPTA1 had increased remarkable,and the change of the level of serum sPTA1 occurred earlier than clinic symptom and that in histopathology,it had decreased rapidly after enhancing the treatment of immune.(Conclusion:The) level of serum sPTA1 is one of credible guideline to distinguish and monitor allograft liver transplantation,the result is consistent with histopathological examination.更多还原