【摘要】 模拟铜一锌超氧化物歧化酶(Cu,Zn-SOD)的活性中心,以二(2-苯并咪唑)丙烷(tbz)为桥、二(2-苯并咪唑亚甲基)胺(N3)、二(2-苯并咪唑亚甲基)甲胺(MN3)及二(2-苯并咪唑亚甲基)苄胺(BN3)为配体合成了3种异双核的小分子模型化合物,并进行了紫外、红外表征及元素分析,推测了可能的结构。采用邻苯三酚自氧化法测定了它们的生物活性,结果表明所合成的配合物具有一定的拟SOD活性。更多还原

【Abstract】 Three kinds of small molecular copper and zinc superoxide dismutase mimics were synthesized with N, N-bis (benzimidazol-2-ylmethyl) amine (N3), N, N-bis (benzimidazol-2-ylmethyl) methylamine(MN3) and N,N-bis (benzimidazol-2-ylmethyl) benzylamine(BN3) as ligands. The com-plexes were characterized by UV, IR and element analysis and the structures were proposed. The bio-logical activities were determined by means of pyrogallol autoxidation. The results showed that these complexes had SOD activities.更多还原