【摘要】 以3,5-二硝基苯甲酰氯、3-氨基丙酸和6-氨基正己酸为原料,室温反应合成了3-(3,5-二硝基苯甲酰氨基)丙酸和6-(3,5-二硝基苯甲酰氨基)正己酸。反应过程中,3,5-二硝基苯甲酰氯分批加入,滴加2 mol/L氢氧化钠水溶液控制反应体系的pH=8~9,n(3,5-二硝基苯甲酰氯)/n(氨基酸)=1,收率分别为84%和81%;硝基化合物经10%钯炭催化剂(用量为反应物质量的10%)催化加氢,再经盐酸酸化,得目标产物3-(3,5-二氨基苯甲酰氨基)丙酸盐酸盐和6-(3,5-二氨基苯甲酰氨基)正己酸盐酸盐,收率分别为93%和94%。相关化合物的结构通过FTIR1、HNMR1、3CNMR进行了表征。更多还原

【Abstract】 3-（3,5-Dinitrobenzoylamido）propanoic acid（Ⅰ） and 6-（3,5-dinitrobenzoylamido） hexanoic acid（Ⅱ） were synthesized respectively by reaction of 3,5-dinitrobenzoyl chloride with 3-aminopropanoic acid and 6-aminohexanoic acid at room temperature.In the experiment,3,5-dinitrobenzoyl chloride should be added in portions,2 mol/L aqueous NaOH solution was dropped into the reaction system to keep pH=8～9,and n（3,5-dinitrobenzoyl chloride）∶n（amino acid）=1.Yields of Ⅰ and Ⅱ are 84% and 81% respectively.The nitro compounds Ⅰ and Ⅱ were hydrogenated with 10%Pd /C as catalyst（m（catalyst）∶m（nitro compound）=10∶100）,and then acidized with hydrochloric acid to get the title compounds 3-（3,5-diaminobenzoylamido）propanoic acid hydrochloride and 6-（3,5-diaminobenzoylamido）hexanoic acid hydrochloride in 93% and 94% yield respectively.Structures of the compounds were confirmed by FTIR,¹HNMR and ¹³CNMR.更多还原